The 1,3,5-triazine is the common triazine moiety. Triazines are weak bases and have much weaker resonance energy than benzene, so nucleophilic substitution is preferred to electrophilic substitution. Heterocyclic bearing triazines moieties, represent an interesting class of compounds possessing a wide spectrum of biological activities such as antiviral, fungicidal, insecticidal, bactericidal, herbicidal and antimalarial, anti-HIV, anticancer, anti-inflammatory, analgesic, antihypertensive, cardiotonic, neuroleptic, nootropic, anti-histamine, tuberculostatic, anti-protozoal, estrogen receptor modulators, cyclin-dependent kinase inhibitors, and antiparasitic activities agents. They also find applications as dyes, lubricants and analytical reagents. Some dyes, lubricants, and reagents derived from triazine are already available on market. By using the same approach series of compounds can be synthesized, characterize and evaluate for desire pharmacological activity with high potency and low toxicity. The triazine derivatives possess diverse biological potential, easy synthetic routes for the synthesis, and attracted researchers for the development of new chemotherapeutic agents and it also revealed the importance of the nucleus.